Tahun Terbit

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Adaptation to hypoxia is essential to survival in most organisms; disruption of oxygen homeostasis is linked to the pathology of multiple diseases including neurodegeneration, ischaemic stroke and cancer. Hypoxia-inducible factor 1 (HIF-1) is a key transcription factor in the detection of oxygen depletion and in mediating the response to hypoxia to maintain cellular oxygen homeostasis. This stu…