The thermodynamic parameters for six p53 carboxy-terminus peptide fragments as determined by analytical ultracentrifugal analysis were compared over the experimental temperature range of 275–310 K to evaluate the Gibbs free energy change as a function of temperature, DGo(T), from 0 to 400 K using our general linear thirdorder fitting function, DGo(T) = a ? bT2 ? cT3. Data obtained at t…